Add to ORKGCardiac stem cells (CSCs) have been implicated as the most suitable source of stem cells in regenerating the diseased heart. However, diabetes is known to cause a progressive loss in the functional efficacy of CSCs. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate genes at the post-transcriptional level. This study investigated whether dysregulation of miRNAs could be the underlying cause for the functional deterioration of diabetic CSCs and whether genetic manipulation of miRNAs can improve their function. Diabetes caused significant dysregulation of miR-329, -495, -376c and -30c in both mouse and human diabetic CSCs. Moreover, elevated expression of miR-30c was suggested to improve the survival of the diabetic CSCs
MicroRNAs (miRNAs) are tiny, endogenous, conserved, non-coding RNAs that negatively modulate gene ex...
The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in hu...
MicroRNAs (miRNAs) are small, non-coding, RNA molecules that regulate gene expression. They have a l...
Cardiac stem cells (CSCs) have been implicated as the most suitable source of stem cells in regenera...
Transplantation of resident cardiac stem cells (CSCs) to the injured myocardium presents the potenti...
Diabetic heart disease (DHD) is often unrecognized in the subclinical stage due to absence of pathog...
Recent findings reveal that more than 70% of diabetic individuals are prone to developing some form ...
Diabetic heart disease (DHD) is often unrecognized in the subclinical stage due to absence of pathog...
Stem cells are considered as the next generation drug treatment in patients with cardiovascular dise...
MicroRNAs (miRNAs) are endogenous, non-coding RNA species that regulate gene expression at the post-...
AIMS Recent randomized trials suggest that intensive glycaemic control fails to reduce heart failur...
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in...
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in...
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in...
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in ...
MicroRNAs (miRNAs) are tiny, endogenous, conserved, non-coding RNAs that negatively modulate gene ex...
The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in hu...
MicroRNAs (miRNAs) are small, non-coding, RNA molecules that regulate gene expression. They have a l...
Cardiac stem cells (CSCs) have been implicated as the most suitable source of stem cells in regenera...
Transplantation of resident cardiac stem cells (CSCs) to the injured myocardium presents the potenti...
Diabetic heart disease (DHD) is often unrecognized in the subclinical stage due to absence of pathog...
Recent findings reveal that more than 70% of diabetic individuals are prone to developing some form ...
Diabetic heart disease (DHD) is often unrecognized in the subclinical stage due to absence of pathog...
Stem cells are considered as the next generation drug treatment in patients with cardiovascular dise...
MicroRNAs (miRNAs) are endogenous, non-coding RNA species that regulate gene expression at the post-...
AIMS Recent randomized trials suggest that intensive glycaemic control fails to reduce heart failur...
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in...
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in...
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in...
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in ...
MicroRNAs (miRNAs) are tiny, endogenous, conserved, non-coding RNAs that negatively modulate gene ex...
The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in hu...
MicroRNAs (miRNAs) are small, non-coding, RNA molecules that regulate gene expression. They have a l...