Reproductive activity and metabolic function are two separate neuroendocrine controlled processes. There is a degree of overlapping hormonal and neuronal regulatory mechanisms. The functional activity of the former is mediated by the HPG axis. GnRH neurons located at the top of the axis regulate the secretion of LH and FSH. These are the primary gonadotropic hormones that act peripherally to convey central instructions to the gonads. Through the HPG axis, the fertility of the animal is primarily regulated. Other inputs, such as those from the metabolic centers of the brain can interfere with fecundity and pubertal onset. The aim of the following thesis was to investigate how necessary MC4R’s on GnRH neurons are in allowing fertility in mice...
Reproductive function is regulated by a plethora of signals that integrate physiological and environ...
GnRH neurons are the final central neural output regulating fertility. Kisspeptin neurons in the hyp...
Altered metabolic status and steroid milieu are relayed to the brain to regulate the secretion of go...
Reproductive activity and metabolic function are two separate neuroendocrine controlled processes. T...
Obesity is a growing problem in the western world, and this is accompanied by an increase in inferti...
Gonadotropin-releasing hormone (GnRH) neurons that reside in the hypothalamus are the central driver...
Reproductive function is an adaptive system that is critical for the survival of all species. In ver...
Introduction: The central regulation of fertility is carefully coordinated with energy homeostasis, ...
Much of the recent research on gonadotropin – related control processes of reproduction and reproduc...
This thesis aimed to investigate the link between gut peptides and reproduction. Briefly, GnRH neuro...
Energy balance exerts a critical influence on reproductive function. Leptin and insulin are among th...
Reproduction involves the integration of hormonal signals acting across multiple systems to generate...
The five melanocortin receptors (MC (1-5)) are part of the G-coupled protein receptor (GPCR) family ...
Energy homeostasis and reproduction need to be tightly coordinated. The mechanisms for this coordina...
Background: Secretion of gonadotropin-releasing hormone (GnRH) produced in neurons in the basal fore...
Reproductive function is regulated by a plethora of signals that integrate physiological and environ...
GnRH neurons are the final central neural output regulating fertility. Kisspeptin neurons in the hyp...
Altered metabolic status and steroid milieu are relayed to the brain to regulate the secretion of go...
Reproductive activity and metabolic function are two separate neuroendocrine controlled processes. T...
Obesity is a growing problem in the western world, and this is accompanied by an increase in inferti...
Gonadotropin-releasing hormone (GnRH) neurons that reside in the hypothalamus are the central driver...
Reproductive function is an adaptive system that is critical for the survival of all species. In ver...
Introduction: The central regulation of fertility is carefully coordinated with energy homeostasis, ...
Much of the recent research on gonadotropin – related control processes of reproduction and reproduc...
This thesis aimed to investigate the link between gut peptides and reproduction. Briefly, GnRH neuro...
Energy balance exerts a critical influence on reproductive function. Leptin and insulin are among th...
Reproduction involves the integration of hormonal signals acting across multiple systems to generate...
The five melanocortin receptors (MC (1-5)) are part of the G-coupled protein receptor (GPCR) family ...
Energy homeostasis and reproduction need to be tightly coordinated. The mechanisms for this coordina...
Background: Secretion of gonadotropin-releasing hormone (GnRH) produced in neurons in the basal fore...
Reproductive function is regulated by a plethora of signals that integrate physiological and environ...
GnRH neurons are the final central neural output regulating fertility. Kisspeptin neurons in the hyp...
Altered metabolic status and steroid milieu are relayed to the brain to regulate the secretion of go...