Background: Bisphosphonate related osteonecrosis of the jaw (BRONJ) is a widely recognised dental side effect of bisphosphonate therapy in which the key finding is a non-healing exposed necrotic bone in the oral cavity. The mechanisms underlying BRONJ are poorly understood. Evidence from previous studies indicates that inhibition of bone remodelling, toxic effects on soft tissues, anti-angiogenic effects, and the inhibition of the mevalonate pathway (MVP) may play a role in BRONJ pathogenesis. Aims: To determine the effects of zoledronic acid (ZA) and replenishment of the MVP by geranylgeraniol (GGOH) on HGFs and HOBs. Methods: HGFs were cultured from gingival tissue (n=5) and HOBs were isolated from mandibular alveolar bone (n=3). HGFs...
[Extract] Recent literature suggests that suppressed angiogenesis contributes significantly to the p...
Bisphosphonates are recommended in the treatment of osteoporosis and some cancers, in which case the...
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) worsens oral health-related quality of life....
Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a widely recognised dental si...
Introduction: Patients treated with nitrogen-containing bisphosphonates, such as zoledronic acid (ZA...
Background: The pathogenesis of bisphosphonate related osteonecrosis of the jaw (BRONJ) is not well...
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication associated with bi...
Background: Osteonecrosis of the jaws is recognised as a serious complication for patients receiving...
Since the first description of bisphosphonate-related osteonecrosis of the jaw (BRONJ), numerous res...
BRONJ is a serious oral complication of BP treatment involving the exposure of necrotic maxillary or...
Recently, bisphosphonates (BPs) have been widely used in medical practice as anti-resorptive agents ...
The mevalonate pathway (MVP) and the anti-angiogenic effect of bisphosphonates have been shown to pl...
PURPOSE:Bisphosphonates related osteonecrosis of jaw (BRONJ) is a severe complication of systemic BP...
Recently, bisphosphonates (BPs) have been widely used in medical practice as anti-resorptive agents ...
Bisphosphonates cause osteoclast apoptosis, thus inhibiting bone resorption and reducing bone loss. ...
[Extract] Recent literature suggests that suppressed angiogenesis contributes significantly to the p...
Bisphosphonates are recommended in the treatment of osteoporosis and some cancers, in which case the...
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) worsens oral health-related quality of life....
Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a widely recognised dental si...
Introduction: Patients treated with nitrogen-containing bisphosphonates, such as zoledronic acid (ZA...
Background: The pathogenesis of bisphosphonate related osteonecrosis of the jaw (BRONJ) is not well...
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication associated with bi...
Background: Osteonecrosis of the jaws is recognised as a serious complication for patients receiving...
Since the first description of bisphosphonate-related osteonecrosis of the jaw (BRONJ), numerous res...
BRONJ is a serious oral complication of BP treatment involving the exposure of necrotic maxillary or...
Recently, bisphosphonates (BPs) have been widely used in medical practice as anti-resorptive agents ...
The mevalonate pathway (MVP) and the anti-angiogenic effect of bisphosphonates have been shown to pl...
PURPOSE:Bisphosphonates related osteonecrosis of jaw (BRONJ) is a severe complication of systemic BP...
Recently, bisphosphonates (BPs) have been widely used in medical practice as anti-resorptive agents ...
Bisphosphonates cause osteoclast apoptosis, thus inhibiting bone resorption and reducing bone loss. ...
[Extract] Recent literature suggests that suppressed angiogenesis contributes significantly to the p...
Bisphosphonates are recommended in the treatment of osteoporosis and some cancers, in which case the...
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) worsens oral health-related quality of life....