The association between inflammation, obesity and elevated blood pressure in 16-25-year-old females

There is evidence to show an association between inflammation, obesity and elevated blood pressure. However, there is limited data for this relationship in adolescent females. We aimed to investigate the association between high sensitivity C-reactive protein (hs-CRP) and elevated blood pressure in young Australian females. Women aged 16–25 years living in Victoria were randomly recruited via targeted Facebook advertising. Socio-demographic information was collected via a web-based questionnaire. Anthropometric and blood pressure measurements were conducted by trained staff. Hs-CRP was assessed using the Abbott Architect assay. The demographic data were collected from 639 females (mean ±s.d. age: 22±3). The blood pressure data were available for 502 participants. Approximately 28% had elevated blood pressure (defined by a blood pressure reading ⩾120–139/80–89 mm Hg for adults and >90th and 3.0 mg l−1 and 30% were overweight or obese. In multivariable logistic regression analyses, obese females (OR: 5.5, 95% CI: 2.4−12.5, P<0.001) were more likely to have elevated blood pressure compared with those with a body mass index (BMI) in the normal range. Elevated hs-CRP levels were associated with an increased odds of elevated blood pressure (OR: 3.4, 95% CI: 1.8−6.3, P