The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
- Tcymbarevich, Irina V
- Eloranta, Jyrki J
- Rossel, Jean-Benoît
- Obialo, Nicole
- Spalinger, Marianne
- Cosin-Roger, Jesus
- Lang, Silvia
- Kullak-Ublick, Gerd A
- Wagner, Carsten A
- Scharl, Michael
- Seuwen, Klaus
- Ruiz, Pedro A
- Rogler, Gerhard
- de Vallière, Cheryl
- Misselwitz, Benjamin
- Swiss IBD Cohort Study Group
Publication date
January 2019
DOI Publisher
Springer Science and Business Media LLCAbstract
Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR65 stimulates cAMP and Rho signalling pathways. We aimed to analyse the clinical and functional relevance of the GPR65 associated single nucleotide polymorphism (SNP) rs8005161
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