Lipase-catalysed selective monoacylation of 1,n-diols with vinyl acetate

3 pages, 1 figure, 2 tables.-- Printed version published Jun 21, 2004.A simple enzymatic methodology for the selective monoacetylation of 1,n-diols (n=5,8) using vinyl acetate is reported. Monoacetylation excesses of 81–87% at 74–90% 1,n-diol conversions were obtained in toluene and diisopropyl ether using Thermomyces lanuginosus lipase (TLL) immobilised on polypropylene powder as catalyst.A simple enzymatic methodology for the selective monoacetylation of 1,n-diols (n=5,8) using immobilised Thermomyces lanuginosus lipase in different organic media is reported.We gratefully acknowledge CICYT (AGL2001-0585) and Generalitat de Catalunya (2001SGR 00342) for financial support.Peer reviewe