Prorocentroic Acid, a Neuroactive Super-Carbon-Chain Compound from the Dinoflagellate Prorocentrum hoffmannianum

Prorocentroic acid (PA) was isolated from the dinoflagellate Prorocentrum hoffmannianum. Relative configurations for its 35 asymmetric centers, were determined by analysis of NMR data including heteronuclear couplings and quantum mechanical calculations. PA was tested by using murine cortical neurons grown on microelectrode-arrays. Long term exposure to subtoxic concentrations induced a significant reorganization of neuronal signaling, mainly by changes in the bursting activity. The observed effects could be due to the activation of a plasticity process.This work has been supported by research grants PID2019- 109476RB-C21 (BIOALGRI), SAF2011-28883-C03-03, CTQ2017- 86994-R (Spanish Ministry of Science and Technology), MAC2/4.6d/249 (EU), GRUPIN 14-021 and GRUPIN IDI/2018/000225 (Asturias Regional Government). AHD thanks CSIC for a JAE-intro grant to CCPeer reviewe