Efikasnost mineralnog i organskog adsorbenta u ublažavanju štetnih efekata zearalenona na status proteina krvnog seruma prasadi

The influence of zearalenone on blood serum protein status and the feasibility of utilizing a modified clinoptilolite and esterified glucomannan to alleviate its harmful effects was examined in two trials, 31 and 29 days long, conducted on a total of 64 pigs (32 each) 60 days old, divided into four groups, each containing 8 pigs. Control groups (K) received noncontaminated feed, while experimental groups received feed supplemented with 3.84 mg/kg in the first trial and 5.12 mg/kg of zearalenone in the second trial. Pigs in the first experimental groups (O-I) were given feed with toxin only. Modified clinoptilolite in the amount of 0.2% and esterified glucomannan in the amount of 0.1% were introduced in contaminated feed of the second (O-II) and the third experimental groups (O-III) of both trials. With the use of contaminated feed, a declining trend of the A/G ratio was observed: decrease of albumin content and increase of globulin content on account of the α globulin fraction. A decrease of the γ globulin fraction was detected at the same time. Total protein concentration was also lower. The application of adsorbents successfully alleviated harmful effects of the F-2 toxin on the affected biochemical parameters in blood serum.Uticaj zearalenona na status proteina krvnog seruma prasadi i mogućnost upotrebe modifikovanog klinoptilolita i esterifikovanog glukomanana za ublažavanje njegovih štetnih efekata ispitivan je kroz dva ogleda, u trajanju od 31 i 29 dana, izvedena na ukupno 64 prasadi (32 u svakom ogledu), 60 dana starih, podeljenih u 4 grupe, po 8 jedinki. Kontrolne grupe (K) u oba ogleda hranjene su smešom bez zearalenona, dok su eksperimentalne grupe dobijale hranu koja je sadržavala 3,84 mg/kg u prvom, odnosno, 5,12 mg/kg zearalenona u drugom ogledu. Prasad prve eksperimentalne grupe oba ogleda dobijala je hranu samo sa toksinom. Istovremeno, modifikovani klinoptilolit u količini 0,2% dodat je u hranu za prasad obe druge eksperimentalne grupe (O-II), dok je u smeši obe treće eksperimentalne grupe (O-III) bio prisutan esterifikovani glukomanan u količini od 0,1%. Upotrebom kontaminirane hrane uočen je opadajući trend A/G odnosa: smanjenje sadržaja albumina i povećanje sadržaja globulina na račun α globulinske frakcije. Istovremeno je otkriveno smanjenje koncentracije ukupnih proteina i relativne zastupljenosti γ globulinske frakcije. Primena adsorbenata uspešno je ublažila štetne efekte F-2 toksina na poremećene biohemijske parametre krvnog seruma