ISSN 2347-954X (Print) Granulomatous Interstitial Nephritis: Histomorphological Features with Review of Literature

Abstract: The term interstitial nephritis denotes inflammation of the interstitium and tubules of the renal parenchyma by inflammatory cells and tubular atrophy with edema hence the term tubule interstitial nephritis is preferable. Chronic tubulo interstitial nephritis presents with prominent fibrosis and few inflammatory cells. Granulomatous interstitial nephritis (GIN) is a rarely encountered special form of chronic tubulo interstitial nephrtitis with an incidence of 0.5 to0.9% in routine biopsies and 0.6% in renal transplant biopsies. Many etiological factors are implicated in this disorder like infections, drugs, autoimmune disorders etc. Patients usually present with compromised renal function with either End stage renal disease or chronic renal failure. As GIN is a treatable condition in most of the situations of renal failure, awareness and understanding of the pathophysiologic al mechanisms along with associated conditions will help in arriving at a definitive diagnosis and treatment