Thrombosis and Risk Factors: A Comment

We read with great interest the recent publication by Akar related to thrombosis and risk factors, in which he reached in conclusion that in case of need only homocysteine (Hcy) levels should be routinely analyzed and not the 5, 10-methylenetetrahydrofolate reductase (mTHFr) 677 T polymorphism [1]. The methylation of Hcy to methionine is catalyzed by the mTHFr enzyme. As far as is known, genetic deficiency of mTHFr is one cause leading to increased plasma Hcy levels [2]. But, it should not be forgotten that Hcy rises in many acquired and genetic conditions In conclusion, even if some researchers contradict, provided that folate status is adequate, there is little clinical value of screening for mTHFr 677C→T genotype in the general population for prediction of venous and arterial occlusive disorders and high Hcy levels of course