Growth Processes for a pulse of leptin in fasting human subjects

Abstract A meal-like transient hyperinsulinemia and hyperglycemia, with a pulse of xamethasone, increased serum leptin levels from baseline by 54±21% at 9 h (P = 0.038). In the absence of transient hyperglycemia, leptin increased significantly after doses of both insulin and xamethasone. The effect of insulin was dose-dependent, with a larger increment of serum leptin at 9 h after the highest dose of insulin (75.2±15.7% vs 21.3±8.5%, P = 0.013). Fasting, with or without dexamethasone, resulted in a significant 20% decrease in leptin from morning basal levels. Conversely, the administration of a pulse of insulin and glucose, in the absence of dexamethasone, prevented the drop in serum leptin observed during fasting, regardless of the insulin dose or the serum glucose elevation. The permissive effect of dexamethasone, a single pulse of insulin triggered a rise in serum leptin in humans, even in the absence of transient hyperglycemia. A single pulse of insulin with glucose can prevent the drop in serum leptin normally observed during fasting. We also find the Growth Processes of Lepti