ABSTRACT To explore the potential role that load-induced fluid flow plays as a mechano-transduction mechanism in bone adaptation, a lacunar-canalicular scale bone poroelasticity model is developed and exercised. The model uses micromechanics to homogenize the pericanalicular bone matrix, a system of straight circular cylinders in the bone matrix through which bone fluids can flow, as a locally anisotropic poroelastic medium. In this work, a simplified two-dimensional model of a periodic array of lacunae and their surrounding systems of canaliculi is developed and exercised to quantify local fluid flow characteristics in the vicinity of a single lacuna. When the cortical bone model is loaded, microscale stress and strain concentrations occur...
Bone is a living tissue which constantly undergoes a complex process of adaptation in response to it...
Osteocytes, the major type of bone cells embedded in the bone matrix and surrounded by the lacunar a...
Osteocytes buried in bone matrix are major mechanosensory cells that regulate bone remodeling in res...
Existing theories for interstitial flows in bone have only examined the contributions from different...
Both the shape of bone organs and the micro-architecture of bone tissue are significantly influenced...
Both the shape of bone organs and the micro-architecture of bone tissue are significantly influenced...
Publisher's PDFThe transport of fluid, nutrients, and signaling molecules in the bone lacunar-canali...
International audienceBone fluid flow and its induced effects on the bone cells are important player...
While the mechanotransductive capability of skeletal tissue has been acknowledged for decades, the e...
Abstract Background An osteon consists of a multi-layered bone matrix and interstitial fluid flow in...
This paper deals with the multiscale description of a single osteon of cortical bones. The cortical ...
Mechanical loads which are macroscopically acting onto bony organs, are known to influence the activ...
Both the shape of bone organs and the micro-architecture of bone tissue are significantly influenced...
Bone tissue is a living biological entity. In particular, it is able to renew itself, which is key f...
Bone is a complex material showing a hierarchical and porous structure but also a natural ability to...
Bone is a living tissue which constantly undergoes a complex process of adaptation in response to it...
Osteocytes, the major type of bone cells embedded in the bone matrix and surrounded by the lacunar a...
Osteocytes buried in bone matrix are major mechanosensory cells that regulate bone remodeling in res...
Existing theories for interstitial flows in bone have only examined the contributions from different...
Both the shape of bone organs and the micro-architecture of bone tissue are significantly influenced...
Both the shape of bone organs and the micro-architecture of bone tissue are significantly influenced...
Publisher's PDFThe transport of fluid, nutrients, and signaling molecules in the bone lacunar-canali...
International audienceBone fluid flow and its induced effects on the bone cells are important player...
While the mechanotransductive capability of skeletal tissue has been acknowledged for decades, the e...
Abstract Background An osteon consists of a multi-layered bone matrix and interstitial fluid flow in...
This paper deals with the multiscale description of a single osteon of cortical bones. The cortical ...
Mechanical loads which are macroscopically acting onto bony organs, are known to influence the activ...
Both the shape of bone organs and the micro-architecture of bone tissue are significantly influenced...
Bone tissue is a living biological entity. In particular, it is able to renew itself, which is key f...
Bone is a complex material showing a hierarchical and porous structure but also a natural ability to...
Bone is a living tissue which constantly undergoes a complex process of adaptation in response to it...
Osteocytes, the major type of bone cells embedded in the bone matrix and surrounded by the lacunar a...
Osteocytes buried in bone matrix are major mechanosensory cells that regulate bone remodeling in res...