Add to ORKGABSTRACT: The epoxidation of carbamazepine (CBZ) and the hydration of the primary epoxide metabolite was studied in microsomes isolated from ten human livers. To study the epoxide hydrolase activity a high-performance liquid-chromatographic method was developed for the analysis of dlhydro-CBZ-trans-diol. There was a pronounced variation between the specimens in the activity of both enzymes
48-h steady-state metabolic balance studies were carried out in 17 adults receiving long-term antico...
Drugs and their metabolites often produce undesirable effects. These may be due to a number of mecha...
Microsomal epoxide hydrolase (HYL1) is a single-gene enzyme responsible for the hydrolysis of epoxid...
The epoxidation of carbamazepine (CBZ) and the hydration of the primary epoxide metabolite was studi...
The disposition of carbamazepine and its metabolite, the 10,11-epoxide, was investigated in isolated...
We investigated whether carbamazepine, which is known to be metabolized to an electrophilic epoxide ...
We investigated whether carbamazepine, which is known to be metabolized to an electrophilic epoxide ...
Unlike other species investigated so far, the human is able to oxidize drugs and environmental chemi...
A comparative bioavailability study of carbamazepine (CBZ) in tablets and a syrup preparation was ca...
The metabolism of carbamazepine (CBZ) and its major metabolite in humans, carbamazepine 10,11-epoxid...
An uncomplicated, sensitive liquid chromatography linked to mass spectrometry (LC/MS) for evaluation...
Simultaneous monitoring of carbamazepine and its metabo-lites is helpful in providing information on...
The objective of this study was to examine aspects of carbamazepine metabolism, in order to contribu...
The character of reactive metabolites formed from carbamazepine (CBZ) was sought In Incubations of 4...
Modifications to the GCMS assay for valproic acid and 12 metabolites were attempted with respect to ...
48-h steady-state metabolic balance studies were carried out in 17 adults receiving long-term antico...
Drugs and their metabolites often produce undesirable effects. These may be due to a number of mecha...
Microsomal epoxide hydrolase (HYL1) is a single-gene enzyme responsible for the hydrolysis of epoxid...
The epoxidation of carbamazepine (CBZ) and the hydration of the primary epoxide metabolite was studi...
The disposition of carbamazepine and its metabolite, the 10,11-epoxide, was investigated in isolated...
We investigated whether carbamazepine, which is known to be metabolized to an electrophilic epoxide ...
We investigated whether carbamazepine, which is known to be metabolized to an electrophilic epoxide ...
Unlike other species investigated so far, the human is able to oxidize drugs and environmental chemi...
A comparative bioavailability study of carbamazepine (CBZ) in tablets and a syrup preparation was ca...
The metabolism of carbamazepine (CBZ) and its major metabolite in humans, carbamazepine 10,11-epoxid...
An uncomplicated, sensitive liquid chromatography linked to mass spectrometry (LC/MS) for evaluation...
Simultaneous monitoring of carbamazepine and its metabo-lites is helpful in providing information on...
The objective of this study was to examine aspects of carbamazepine metabolism, in order to contribu...
The character of reactive metabolites formed from carbamazepine (CBZ) was sought In Incubations of 4...
Modifications to the GCMS assay for valproic acid and 12 metabolites were attempted with respect to ...
48-h steady-state metabolic balance studies were carried out in 17 adults receiving long-term antico...
Drugs and their metabolites often produce undesirable effects. These may be due to a number of mecha...
Microsomal epoxide hydrolase (HYL1) is a single-gene enzyme responsible for the hydrolysis of epoxid...