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Abstract Objectives: There is evidence that yoga practice is associated with dec reased stre ss, worry, and depre ss i on, and with improved mindfulness-based skills. These findings had not been previously replicated for a sample of college students. This study evaluated whether iRest yoga-nidra practice was associated with reduced perceived stress, worry, and depression, and i nc reased mind ful ne ss in a sample of coll e ge stu d e nt s . Methods: Sixty-six students age 18-56 completed an 8-week iRest yoga-nidra intervention that was offered for 8 semesters. Assessment occurred 1 week prior to intervention onset and during the class period following the intervention. Qualitative data were collected at Weeks 4 and 8. Results: Statistically significant pre-to posttest improvements in perceived stress, worry, and depre ss i on we re fou nd. Pree x isti ng depre ss i on accounted for most of the change in worry and perceived stress scores. Pre-to posttest improvements in mindfulness-based skills were also detected. Conclusions: iRest yoga-nidra practice may reduce symptoms of perceived stress, worry, and depression and increase mindfulness-based skills