Formulation and Evaluation of Piroxicam Solid Dispersion with Suitable Carrier

ABSTRACT Piroxicam is a long acting potent NSAID with inflammatory potency and good analgesic-antipyretic action. It is a reversible inhibitor of COX lowers PG concentration in synovial fluid and inhibits platet aggregation prolonging bleeding time. In addition it decreases to IgM rehumatoid factor and leucocyte chemotaxis. Thua it can inhibit inflammation in diverse ways. Solid dispersion were by preliminary solubility analysis was carried out for the selection of carriers and solid dispersion was prepared with PEG 4000 PEG 6000 and mannitol. To increase the solubility of drug solid dispersion was prepared. These solid dispersions were analysed for the solubility and Invitro dissolution profile, solid dispersion of drug with PEG 6000 had shown enhanced solubility with improved dissolution rate. The FTIR and DSC studies revealed that there is no interaction between drug and carriers. Solid dispersion prepared with PEG 4000 shows the presence of amorphous form confirmed by the characterization study like SEM sudies. The study also shows the dissolution rate of Piroxicam can be enhanced to considerable extent by solid dispersion technique with PEG