Tonic Pain Perception in the Mouse: Differential Modulation by Three Receptor-.Selective Opioid Agonists'

ABSTRACT ABBREVIATIONS: Ago, doSe of agonist required to produce 50% mean analgesia; CI, confidence interval; DPDPE, The proposition that tonic nociception models are more analogous to clinical pain than traditional acute models prompted our previous development of a modified mouse paw formalin test. To discern possible modulatory roles and site(s) of action of endogenous opiold systems, the receptor-preferring agonists sufentanil (mu), U-50,488H (kappa) an