Comapartive Study on Hepatoprotective activity of Phyllanthus amarus and Eclipta prostrata against alcohol induced in albino rats

ABSTRACT Our research studies data suggest that, there were significant variations in the observed biochemical parameters. The level of TBARS in ethanol intoxicated rats increased two fold when compared with the control animals. The levels of GSH, SOD and CAT decreased significantly in the ethanol intoxicated rats. The level of GPx was increased in the ethanol intoxicated rats. The value of vitamin E in both plasma and liver samples were less when compared with the control animals. Similarly, the value of vitamin C was also showed decreased level in plasma. Serum iron and copper levels were elevated to a higher level. The therapeutic administrations of Phyllanthus amarus and Eclipta prostrata leaves fine powder greatly change the biochemical parameters in the ethanol intoxicated rats and maintained well to the normal level. These results clearly suggest that, the Phyllanthus amarus and Eclipta prostrata have enormous hepatoprotective value. Among the two plants Phyllanthus amarus has slightly high activity as compare to Eclipta prostrata. These herbal drugs have equivalent therapeutic value with the standards drug Silymarin. Moreover, it is very important to study the specific phytochemical compounds responsible for this hepatoprotective effect