Experimental Goettingen minipig and beagle dog as two species used in bioequivalence studies for clinical pharmacology (5-aminosalicylic acid and atenolol as model drugs). Gen Physiol Biophys 18: 80–85

Abstract. Due to proven similarities in biotransformation between man and mini pig, minipig seems to be the experimental animal of choice for preclinical phar macokinetic studies when an experiment with a drug exhibiting a great first pass bioelimination (like 5-aminosalicylic acid) is to be realised. On the other hand, both minipig and dog may be suitable species for a pharmacokinetic study with a drug characterized by a small extent of first pass biotransformation (like atenolol)