Small RNAs and Cancerogenesis

During recent years, new mechanisms of regulation of gene expression have been discovered. These mechanisms are based on complementary interaction of short RNA (of 20-30 nucleotides in length) with their mRNA targets or nascent transcripts within chromatin Discussion of this topic may help to foresee future directions in studies of the epigenomics of cancer. The discovery of the phenomenon known as RNA interference (RNAi) has demonstrated, that exogenously administered or artificially expressed double stranded RNAs (dsRNA) selectively inhibit expression of target genes with homologous nucleotide sequence Results of these studies have been summarized in several review