In vitro Antiplasmodial Activity of Some Medicinal Plants Used in Folk Medicine in Burkina Faso Against Malaria

Abstract: The aim of this study was to evaluate the in vitro antiplasmodial activities of four plants used in traditional medicine. Hydroethanolic extract, hydroacetonic extract and aqueous extract of Mitragyna inermis (Willd.) O. Kuntze (Rubiaceae), Combretum sericeum G. Don (Combretaceae), Alternanthera pungens H.B. and K (Amaranthaceae) and Ampelocissus grantii (Baker) Planch (Vitaceae) have been tested in vitro against chloroquine-resistant strain (K1) and chloroquine-sensitve strain (3D7) of Plasmodium falciparum using pLDH assay. Aqueous extracts exhibited the best results against K1 with the 50% inhibitory concentration (IC 50 ) values of 0.54±0.18, 1.72±0.99, 1.54±0.04 :g/mL for respectively, M. inermis leaves, C. sericeum leaves and whole plant of A. pungens. Hydroethanolic extract from the leaves of M. inermis gave also IC 50 value of 0.87±0.10 :g/mL with 3D7. Extracts showed antiplasmodial activity against both chloroquine-sensitive and chloroquine-resistant P. falciparum strains. Our study justifies the use of these plants in traditional medicine and leads to further investigations