Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscaninic receptors in munine neuroblastoma cells

ABSTRACT a protein kinase C inhibitor. PMA had no effect on binding of an antagonist ligand to muscannic receptors, or on the binding characteristics of CBC to these receptors in intact cells. On the other hand, PMA competed for the specific binding of a labeled phorbol ester in intact cells with a potency similar to that of PMA in inhibiting muscannic receptor-mediated [3H]cyclic GMP responses