Personal non-commercial use only

ABSTRACT. Objective. To examine the extent of polysomnographic (PSG) sleep disturbances [obstructive apnea hypopnea index (OAHI), number of wake bouts, arousals, periodic limb movements] and the effect of OAHI on neurobehavioral performance in juvenile idiopathic arthritis (JIA) with obstructive sleep apnea (OSA), JIA without OSA, and controls without OSA, adjusting for intelligence quotient (IQ), pain, medications, daytime sleepiness, and wake bouts. Methods. life) 4,5 . In our previous study 6 of 73 children with juvenile idiopathic arthritis (JIA), 40% had an elevated apnea/hypopnea index suggestive of OSA, and 19% of these children showed physiological daytime sleepiness on multiple sleep latency tests (MSLT). Regardless of active or inactive JIA, the apnea/hypopnea index was inversely associated with reaction time (RTI; p < 0.001), and the number of wake bouts (an indicator of sleep fragmentation) was inversely associated with RTI and with the probability of making a correct response (p < 0.05), controlling for intelligence quotient (IQ), medications, and pain 6 . These findings were the first to link physiologic objective measures of sleep disturbance with validated cognitive test results in JIA. However, we did not examine whether the associations between OSA and altered neurobehavioral function were unique to JIA, JIA and OSA, or represented similar effects in healthy children. The objectives of our current study were to examine the extent of polysomnographic (PSG) sleep disturbances [obstructive apnea hypopnea index (OAHI), number of wake bouts, arousals, periodic limb movements] and the effect of OAHI on neurobehavioral performance in JIA with OSA, JIA without OSA, and controls without OSA, adjusting for IQ, maternal education, pain, medications, daytime sleepiness, and wake bouts. Based on our prior findings of OSA, daytime sleepiness, and altered neurobehavioral performance in JIA, we hypothesized that JIA with OSA would have increased OAHI, increased daytime sleepiness, slower movement time Sleep disturbance from obstructive sleep apnea (OSA) is a costly 1,2 serious health concern 3 associated with negative health outcomes (e.g., daytime sleepiness, lower quality o