Comparative Study on the Efficiency of Various Binder Combinations for Metformin Tablets

ABSTRACT Metformin hydrochloride is widely used as an oral anti hypoglycemic agent. But it is difficult to formulate by direct compression method because of its poor compaction properties and its crystalline nature. The present study target for a better combination of binders that produces metformin tablets with unique results. The granulation is done using binder combination of gelatin, PVP K 30, HPMC, Cross Povidone, starch and Kyron-T 314. The wet granulation method is selected for the formulation of metformin tablets and the formulated tablets were evaluated for their hardness, friability, disintegration, content uniformity and dissolution profiles with USP type II apparatus at 100 rpm in pH 6.8 phosphate buffer solution. Th