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ABSTRACT The present study aims at determining effectiveness of cognitive behavioral therapy and treatment based on taking Buspirone on controlling temptation of opium addicts. semi-experimental research method with pretest -posttest and control group was used. All people under treatment with methadone in Omid-eKhanevadeh Medical Center in Islamshahr consisted research population and the research sample included 60 subjects which were selected randomly. The subjects were assigned in four groups of 15. Following implementing pretest, three experimental groups were treated using 1. Cognitive behavioral therapy 2. Cognitive behavioral therapy and Buspirone based treatment, and 3. Buspirone based treatment, while no intervention was used in fourth group (control group). Research tool was Golparvar's Drug Tendency Test which was implemented in pretest and posttest. Multivariate analysis of covariance was used for data analysis. Findings indicate reduction of temptation in people under cognitive behavioral therapy compared to people under Buspirone and methadone treatment. Cognitive behavioral therapy is effective in reduction of temptation to opium. Keywords: Opium Addicts, Cognitive Behavioral Therapy, Temptation, Buspirone INTRODUTION Many people daily come to use drugs and got involved in its physical, mental, cultural, family, economic, and social consequence