DMD #7435 Expression of UDP-Glucuronosyltransferase Isoform mRNAs during Inflammation and Infection in Mouse Liver and Kidney DMD #7435 2 Running Title: Hepatic and renal UGT mRNA expression during inflammation

Citrobacter rodentium by oral gavage (6 days). Hepatic mRNA expression of UGT1A1, 1A9, and 2B5 were similarly down-regulated after LPS exposure and C. rodentium infection, whereas UGT1A2 and 1A6 mRNAs were unchanged. Effects of C. rodentium infection did not require a functional Toll-like receptor 4 (TLR4). Conversely, renal UGT isoforms were relatively unaffected, except for UGT2B5 induction after LPS treatment. Regulation of UGTs during the inflammatory response exhibits similarities and differences with regulation of P450s, and may be cytokine-mediated