ABSTRACT The glucagon-like peptide-1 receptor (GLP-1R) is a major therapeutic target for the treatment of type 2 diabetes due to its role in glucose homeostasis. Despite the availability of peptide-based GLP-1R drugs for treatment of this disease, there is great interest in developing small molecules that can be administered orally. The GLP-1R system is complex, with multiple endogenous and clinically used peptide ligands that exhibit different signaling biases at this receptor. This study revealed that small molecule ligands acting at this receptor are differentially biased to peptide ligands and also from each other with respect to the signaling pathways that they activate. Furthermore, allosteric small molecule ligands were also able to ...
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of insulin biosynthesis and ...
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a major the...
The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles in regulat...
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of insulin biosynthesis and ...
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a major the...
Glucagon-like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion and promotes β-cell fun...
The incidence of type 2 diabetes in developed countries is increasing yearly with a significant nega...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Glucagon-like peptide-1 (GLP-1) mediates antidiabetogenic effects through the GLP-1 receptor (GLP-1R...
The glucagon-like peptide receptor (GLP-1R), which is a G-protein coupled receptor (GPCR), signals t...
Glucagon-like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion and promotes β-cell fun...
The glucagon-like peptide-1 receptor (GLP-1R) potentiates glucose-stimulated insulin release from pa...
The glucagon-like peptide-1 receptor (GLP-1R) is a family B G protein-coupled receptor and an import...
Glucagon-like peptide-1 (GLP-1) mediates antidiabetogenic effects through the GLP-1 receptor (GLP-1R...
The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles in regulat...
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of insulin biosynthesis and ...
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a major the...
The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles in regulat...
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of insulin biosynthesis and ...
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a major the...
Glucagon-like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion and promotes β-cell fun...
The incidence of type 2 diabetes in developed countries is increasing yearly with a significant nega...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Glucagon-like peptide-1 (GLP-1) mediates antidiabetogenic effects through the GLP-1 receptor (GLP-1R...
The glucagon-like peptide receptor (GLP-1R), which is a G-protein coupled receptor (GPCR), signals t...
Glucagon-like peptide-1 (GLP-1) enhances glucose-dependent insulin secretion and promotes β-cell fun...
The glucagon-like peptide-1 receptor (GLP-1R) potentiates glucose-stimulated insulin release from pa...
The glucagon-like peptide-1 receptor (GLP-1R) is a family B G protein-coupled receptor and an import...
Glucagon-like peptide-1 (GLP-1) mediates antidiabetogenic effects through the GLP-1 receptor (GLP-1R...
The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles in regulat...
The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of insulin biosynthesis and ...
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a major the...
The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles in regulat...