T cell suppression is a well established phenomenon, but the mechanisms involved are still a matter of debate. Mouse anergic T cells were shown to suppress responder T cell activation by inhibiting the antigen presenting function of DC. In the present work we studied the effects of co-culturing human anergic CD4 þ T cells with autologous dendritic cells (DC) at different stages of maturation. Either DC maturation or survival, depending on whether immature or mature DC where used as APC, was impaired in the presence of anergic cells. Indeed, MHC and costimulatory molecule up-regulation was inhibited in immature DC, whereas apoptotic phenomena were favored in mature DC and consequently in responder T cells. Defective ligation of CD40 by CD40L...
Item does not contain fulltextDendritic cells (DC) are professional antigen-presenting cells which a...
CD4 memory T cells play an important role in induction of autoimmunity and chronic inflammatory resp...
Ligation of the T cell receptor (TCR) by self-antigen/MHC complexes results in T cell activation or ...
T cell suppression is a well established phenomenon, but the mechanisms involved are still a matter ...
T cell suppression is a well established phenomenon, but the mechanisms involved are still a matter ...
Anergic/suppressive CD4+CD25+ T cells exist in animal models but their presence has not yet been dem...
Cell death via apoptosis is a normal physiological process. Rapid, but silent, removal of apoptotic ...
Immature dendritic cells (DC) represent potential clinical tools for tolerogenic cellular immunother...
Immature dendritic cells (DC) represent potential clinical tools for tolerogenic cellular immunother...
Over the last decade the notion has prevailed that immature, quiescent dendritic cells (DC) induce t...
© 2015 Maggi, Schafer, Ubilla-Olguín, Catalán, Schinnerling and Aguillón. The interaction between de...
BACKGROUND: In this study, we have investigated the mechanisms involved in both the induction of sup...
AbstractWe report that disruption of CD154 in nonobese diabetic (NOD) mice abrogates the helper func...
OBJECTIVE: There is a breakdown of tolerance to neutrophil components during systemic vasculitis, wh...
Dendritic cells (DC) form a specialized system for presenting Ag to naive or quiescent T cells and c...
Item does not contain fulltextDendritic cells (DC) are professional antigen-presenting cells which a...
CD4 memory T cells play an important role in induction of autoimmunity and chronic inflammatory resp...
Ligation of the T cell receptor (TCR) by self-antigen/MHC complexes results in T cell activation or ...
T cell suppression is a well established phenomenon, but the mechanisms involved are still a matter ...
T cell suppression is a well established phenomenon, but the mechanisms involved are still a matter ...
Anergic/suppressive CD4+CD25+ T cells exist in animal models but their presence has not yet been dem...
Cell death via apoptosis is a normal physiological process. Rapid, but silent, removal of apoptotic ...
Immature dendritic cells (DC) represent potential clinical tools for tolerogenic cellular immunother...
Immature dendritic cells (DC) represent potential clinical tools for tolerogenic cellular immunother...
Over the last decade the notion has prevailed that immature, quiescent dendritic cells (DC) induce t...
© 2015 Maggi, Schafer, Ubilla-Olguín, Catalán, Schinnerling and Aguillón. The interaction between de...
BACKGROUND: In this study, we have investigated the mechanisms involved in both the induction of sup...
AbstractWe report that disruption of CD154 in nonobese diabetic (NOD) mice abrogates the helper func...
OBJECTIVE: There is a breakdown of tolerance to neutrophil components during systemic vasculitis, wh...
Dendritic cells (DC) form a specialized system for presenting Ag to naive or quiescent T cells and c...
Item does not contain fulltextDendritic cells (DC) are professional antigen-presenting cells which a...
CD4 memory T cells play an important role in induction of autoimmunity and chronic inflammatory resp...
Ligation of the T cell receptor (TCR) by self-antigen/MHC complexes results in T cell activation or ...