Subchronic Toxicity of Ganoderma Lucidum Polysaccharide Peptide (PsP) to Liver Physiology and HistopathologyImaging of Liver on Rattus Norvegicus Strain Wistar Rats

ABSTRACT The current study evaluated the effect of subchronic toxicity of Ganoderma lucidum Polysaccharides peptide (PsP) to liver physiology and histopatology in rats. The 80 rats were randomly divided into four groups male and four groups female (10 rats per group): Three PsP treated group: 300, 600, 1200 mg/KgBW, and one normal control group. Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphate (ALP) levels of rats were measured, and histopathology changes: the average of cloudy degeneration, ballooning degenaration, the number of kupfer cell, inflamation cell and necrotizing cell were examinated, after 90 days of treatment with Ganoderma lucidum PsP, the ANOVA test show that AST, ALT and ALP levels of the PsP treated group was not significantly different than the control group, and the histopathology anatomy of the liver wasn't show any different with the control group. These data suggest that Ganoderma lucidum PsP on all of the 3 doses was not cause any harm effect to liver enzymes neither to liver tissues