This article is available online at http://dmd.aspetjournals.org ABSTRACT: The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases of toxicity were described in Dr. Gillette's laboratory in the 1970s. These findings indicated that acetaminophen was metabolically activated by cytochrome P450 enzymes to a reactive metabolite that depleted glutathione (GSH) and covalently bound to protein. It was shown that repletion of GSH prevented the toxicity. This finding led to the development of the currently used antidote N-acetylcysteine. The reactive metabolite was subsequently identified to be N-acetyl-p-benzoquinone imine (NAPQI). Although covalent binding has been shown...
Artículo de publicación ISIAdverse reactions of acetaminophen have been associated to oxidative stre...
The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-parabenzoquinon...
Acetaminophen (APAP), the most commonly sold over-the-counter antipyretic analgesic, is generally co...
Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and...
The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs wor...
Thesis (Ph. D.)--University of Washington, 1984The metabolism of drugs and other xenobiotics normall...
INTRODUCTION:Vascular injury and accumulation of red blood cells in the space of Disse (hemorrhage) ...
Acetaminophen (AAP) is one of the most common and widely used antipyretic drugs, but its overdose is...
Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress. However, its ...
Acetaminophen (APAP), a widely used analgesic/antipyretic agent, can cause liver injury through incr...
Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over-the-counter antipyr...
Background: A majority of people widely use acetaminophen as a sedative. Overusing the drug for prol...
Severe liver injury as a result of overdose or chronic use of acetaminophen (paracetamol) remains a ...
BACKGROUND & AIMS: Acetaminophen overdose in mice is characterized by hepatocyte endoplasmic reticul...
The hepatotoxicity of acetaminophen (APAP) is generally attributed to the formation of a reactive qu...
Artículo de publicación ISIAdverse reactions of acetaminophen have been associated to oxidative stre...
The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-parabenzoquinon...
Acetaminophen (APAP), the most commonly sold over-the-counter antipyretic analgesic, is generally co...
Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and...
The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs wor...
Thesis (Ph. D.)--University of Washington, 1984The metabolism of drugs and other xenobiotics normall...
INTRODUCTION:Vascular injury and accumulation of red blood cells in the space of Disse (hemorrhage) ...
Acetaminophen (AAP) is one of the most common and widely used antipyretic drugs, but its overdose is...
Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress. However, its ...
Acetaminophen (APAP), a widely used analgesic/antipyretic agent, can cause liver injury through incr...
Acetaminophen (N-acetyl-p-aminophenol, APAP) is one of the most widely used over-the-counter antipyr...
Background: A majority of people widely use acetaminophen as a sedative. Overusing the drug for prol...
Severe liver injury as a result of overdose or chronic use of acetaminophen (paracetamol) remains a ...
BACKGROUND & AIMS: Acetaminophen overdose in mice is characterized by hepatocyte endoplasmic reticul...
The hepatotoxicity of acetaminophen (APAP) is generally attributed to the formation of a reactive qu...
Artículo de publicación ISIAdverse reactions of acetaminophen have been associated to oxidative stre...
The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-parabenzoquinon...
Acetaminophen (APAP), the most commonly sold over-the-counter antipyretic analgesic, is generally co...