Remarkable efficacy of immune checkpoint inhibition has been reported for several types of solid tumors and early studies in gastric adenocarcinoma are promising. A detailed knowledge about the natural biology of immune checkpoints in gastric adenocarcinoma is essential for clinical and translational evaluation of these drugs. This study is a comprehensive analysis of cytotoxic T lymphocyte associated molecule 4 (CTLA-4) and programmed death 1 ligand 1 (PD-L1) expression in gastric adenocarcinoma. PDL1 and CTLA-4 were stained on tumor sections of 127 Caucasian patients with gastric adenocarcinoma by immunohistochemistry (IHC) and somatic mutation profiling was performed using targeted next-generation sequencing. Expression of PD-L1 and CTLA...
Objective: The programmed cell death-1 receptor/programmed cell death-1 ligand (PD-1/PD-L1) pathway ...
Esophageal and gastric cancers represent tumors with poor prognosis. Unfortunately, radiotherapy, ch...
Advanced gastric cancer (AGC) has high morbidity and mortality in East Asia, and it is urgent to exp...
Remarkable efficacy of immune checkpoint inhibition has been reported for several types of solid tum...
Gastric adenocarcinoma is one of the most common causes of cancer-related death. In this study, we c...
Targeting the immune checkpoint receptors cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell...
Genetic and/or epigenetic changes provide antigen-derived diversity in neoplastic cells. Beside, the...
Abstract Background Anti-programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immunotherapy has...
AbstractCancers can be recognized by the immune system, and the immune system may regulate and even ...
Immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4) and the programmed cell deat...
<div><p>Background</p><p>Immune checkpoint regulators, <i>cytotoxic T lymphocyte antigen 4</i> (CTLA...
Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by hos...
Background: The outlook for patients with esophageal and gastric (EG) cancer remains poor. Hence, th...
The prognosis of esophageal cancers is poor and novel approaches are urgently needed. Despite improv...
Background. Although multiple types of cancers demonstrated favorable outcome after immunotherapy of...
Objective: The programmed cell death-1 receptor/programmed cell death-1 ligand (PD-1/PD-L1) pathway ...
Esophageal and gastric cancers represent tumors with poor prognosis. Unfortunately, radiotherapy, ch...
Advanced gastric cancer (AGC) has high morbidity and mortality in East Asia, and it is urgent to exp...
Remarkable efficacy of immune checkpoint inhibition has been reported for several types of solid tum...
Gastric adenocarcinoma is one of the most common causes of cancer-related death. In this study, we c...
Targeting the immune checkpoint receptors cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell...
Genetic and/or epigenetic changes provide antigen-derived diversity in neoplastic cells. Beside, the...
Abstract Background Anti-programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immunotherapy has...
AbstractCancers can be recognized by the immune system, and the immune system may regulate and even ...
Immune checkpoint regulators, cytotoxic T lymphocyte antigen 4 (CTLA-4) and the programmed cell deat...
<div><p>Background</p><p>Immune checkpoint regulators, <i>cytotoxic T lymphocyte antigen 4</i> (CTLA...
Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by hos...
Background: The outlook for patients with esophageal and gastric (EG) cancer remains poor. Hence, th...
The prognosis of esophageal cancers is poor and novel approaches are urgently needed. Despite improv...
Background. Although multiple types of cancers demonstrated favorable outcome after immunotherapy of...
Objective: The programmed cell death-1 receptor/programmed cell death-1 ligand (PD-1/PD-L1) pathway ...
Esophageal and gastric cancers represent tumors with poor prognosis. Unfortunately, radiotherapy, ch...
Advanced gastric cancer (AGC) has high morbidity and mortality in East Asia, and it is urgent to exp...