Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

Vasseur, Antoine
Cabel, Luc
Trédan, Olivier
Chevrier, Marion
Dubot, Coraline
Lorgis, Veronique
Jacot, William
Gonçalves, Anthony
Debled, Marc
Lévy, Christelle
Ferrero, Jean-Marc
Jouannaud, Christelle, G
Luporsi, Elisabeth
Mouret-Reynier, Marie-Ange
Dalenc, Florence
Lemonnier, Jérôme
Savignoni, Alexia
Tanguy, Marie-Laure
Bidard, François-Clément
Pierga, Jean-Yves

Open link

Publication date

May 2020

DOI

10.1007/s10456-019-09697-7

Publisher

Springer Verlag

Abstract

International audienceProof of concept studies has reported that circulating endothelial cell (CEC) count may be associated with the outcome of HER2-negative metastatic breast cancer (mBC) patients treated by chemotherapy and the anti-VEGF antibody bevacizumab. We report the results obtained in an independent prospective validation cohort (COMET study, NCT01745757)

Extracted data

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Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

Vasseur, Antoine
Cabel, Luc
Trédan, Olivier
Chevrier, Marion
Dubot, Coraline
Lorgis, Veronique
Jacot, William
Gonçalves, Anthony
Debled, Marc
Lévy, Christelle
Ferrero, Jean-Marc
Jouannaud, Christelle, G
Luporsi, Elisabeth
Mouret-Reynier, Marie-Ange
Dalenc, Florence
Lemonnier, Jérôme
Savignoni, Alexia
Tanguy, Marie-Laure
Bidard, François-Clément
Pierga, Jean-Yves

Open link

Publication date

May 2020

DOI

10.1007/s10456-019-09697-7

Publisher

Springer Verlag

Abstract

Extracted data

Giuliano M.
Giordano A.
Jackson S.
Hess K. R.
De Giorgi U.
Mego M.
Handy B. C.
Ueno N. T.
Alvarez R. H.
De Laurentiis M.
De Placido S.
Valero V.
Hortobagyi G. N.
Reuben J. M.
Cristofanilli M.

January 2011

Introduction: Circulating tumor cells (CTCs) represent an independent predictor of outcome in patien...

Circulating tumor cell number and endocrine therapy index in ER positive metastatic breast cancer patients

Costanza Paoletti
Meredith M. Regan
Samuel M. Niman
Emily M. Dolce
Elizabeth P. Darga
Minetta C. Liu
P. Kelly Marcom
Lowell L. Hart
John W. Smith
Karen L. Tedesco
Eitan Amir
Ian E. Krop
Angela M. DeMichele
Pamela J. Goodwin
Margaret Block
Kimberly Aung
Martha E. Brown
Robert T. McCormack
Daniel F. Hayes

June 2021

Abstract Circulating tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). The CTC-end...

Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

Vasseur, Antoine
Cabel, Luc
Trédan, Olivier
Chevrier, Marion
Dubot, Coraline
Lorgis, Veronique
Jacot, William
Gonçalves, Anthony
Debled, Marc
Lévy, Christelle
Ferrero, Jean-Marc
Jouannaud, Christelle,
Luporsi, Elisabeth
Mouret-Reynier, Marie-Ange
Dalenc, Florence
Lemonnier, Jérôme
Savignoni, Alexia
Tanguy, Marie-Laure
Bidard, François-Clément
Pierga, Jean-Yves

May 2020

International audienceProof of concept studies has reported that circulating endothelial cell (CEC) ...

Prognostic value of a high level of circulating endothelial cells in patients with HER2-recurrent or metastatic breast cancer treated with bevacizumab in combination with paclitaxel and gemcitabine as fi rst-line therapy

Manso, L
Ciruelos, E
Codes, M
De la Haba, J
Galan, A
Baena, J
Jaen, A
Gil, M
Murias, A
Blancas, I
Gonzalez, E
Perez, D
Bayo, JL
Mel, J
Garcia-Martinez, E
Cubedo, R
Salvador, J

November 2011

Circulating endothelial cells (CECs) are shed from vessels and enter the circulation reflecting endo...

Clinical value of circulating endothelial cells and circulating tumor cells in metastatic breast cancer patients treated first line with bevacizumab and chemotherapy.

Bidard, François-Clément
Mathiot, Claire
Degeorges, Armelle
Etienne-Grimaldi, Marie-Christine
Delva, R.
Pivot, Xavier, B.
Veyret, C.
Bergougnoux, L.
de Cremoux, Patricia
Milano, Gérard
Pierga, Jean-Yves

March 2010

International audienceBACKGROUND: We investigated whether circulating tumor cells (CTCs) and circula...

Circulating Tumour Cells and pathological complete response: independent prognostic factors in inflammatory breast cancer in a pooled analysis of two multicentre phase II trials (BEVERLY-1 and -2) of neoadjuvant chemotherapy combined with bevacizumab

Pierga, J-y
Bidard, F-C
Autret, A.
Petit, T.
André, F.
Dalenc, F.
Lévy, C.
Ferrero, J-M
Romieu, G.
Bonneterre, J.
Lerebours, F.
Bachelot, Thomas
Kerbrat, P.
Campone, M.
Eymard, J-C
Mouret-Reynier, M-A
Gligorov, J.
Hardy-Bessard, A-C
Lortholary, A.
Soulie, P.
Boher, J-M
Proudhon, C.
Charafe-Jaufret, E.
Lemonnier, J.
Bertucci, F.
Viens, P.

January 2017

International audienceBackground: We present a pooled analysis of predictive and prognostic values o...

Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment

Giuliano M.
Giordano A.
Jackson S.
Hess K. R.
De Giorgi U.
Mego M.
Handy B. C.
Ueno N. T.
Alvarez R. H.
De Laurentiis M.
De Placido S.
Valero V.
Hortobagyi G. N.
Reuben J. M.
Cristofanilli M.

January 2011

Introduction: Circulating tumor cells (CTCs) represent an independent predictor of outcome in patien...

Circulating tumor cell number and endocrine therapy index in ER positive metastatic breast cancer patients

Costanza Paoletti
Meredith M. Regan
Samuel M. Niman
Emily M. Dolce
Elizabeth P. Darga
Minetta C. Liu
P. Kelly Marcom
Lowell L. Hart
John W. Smith
Karen L. Tedesco
Eitan Amir
Ian E. Krop
Angela M. DeMichele
Pamela J. Goodwin
Margaret Block
Kimberly Aung
Martha E. Brown
Robert T. McCormack
Daniel F. Hayes

June 2021

Abstract Circulating tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). The CTC-end...

Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

Vasseur, Antoine
Cabel, Luc
Trédan, Olivier
Chevrier, Marion
Dubot, Coraline
Lorgis, Veronique
Jacot, William
Gonçalves, Anthony
Debled, Marc
Lévy, Christelle
Ferrero, Jean-Marc
Jouannaud, Christelle,
Luporsi, Elisabeth
Mouret-Reynier, Marie-Ange
Dalenc, Florence
Lemonnier, Jérôme
Savignoni, Alexia
Tanguy, Marie-Laure
Bidard, François-Clément
Pierga, Jean-Yves

May 2020

International audienceProof of concept studies has reported that circulating endothelial cell (CEC) ...

Manso, L
Ciruelos, E
Codes, M
De la Haba, J
Galan, A
Baena, J
Jaen, A
Gil, M
Murias, A
Blancas, I
Gonzalez, E
Perez, D
Bayo, JL
Mel, J
Garcia-Martinez, E
Cubedo, R
Salvador, J

November 2011

Circulating endothelial cells (CECs) are shed from vessels and enter the circulation reflecting endo...

Clinical value of circulating endothelial cells and circulating tumor cells in metastatic breast cancer patients treated first line with bevacizumab and chemotherapy.

Bidard, François-Clément
Mathiot, Claire
Degeorges, Armelle
Etienne-Grimaldi, Marie-Christine
Delva, R.
Pivot, Xavier, B.
Veyret, C.
Bergougnoux, L.
de Cremoux, Patricia
Milano, Gérard
Pierga, Jean-Yves

March 2010

International audienceBACKGROUND: We investigated whether circulating tumor cells (CTCs) and circula...

Pierga, J-y
Bidard, F-C
Autret, A.
Petit, T.
André, F.
Dalenc, F.
Lévy, C.
Ferrero, J-M
Romieu, G.
Bonneterre, J.
Lerebours, F.
Bachelot, Thomas
Kerbrat, P.
Campone, M.
Eymard, J-C
Mouret-Reynier, M-A
Gligorov, J.
Hardy-Bessard, A-C
Lortholary, A.
Soulie, P.
Boher, J-M
Proudhon, C.
Charafe-Jaufret, E.
Lemonnier, J.
Bertucci, F.
Viens, P.

January 2017

International audienceBackground: We present a pooled analysis of predictive and prognostic values o...

Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment

Giuliano M.
Giordano A.
Jackson S.
Hess K. R.
De Giorgi U.
Mego M.
Handy B. C.
Ueno N. T.
Alvarez R. H.
De Laurentiis M.
De Placido S.
Valero V.
Hortobagyi G. N.
Reuben J. M.
Cristofanilli M.

January 2011

Introduction: Circulating tumor cells (CTCs) represent an independent predictor of outcome in patien...

Circulating tumor cell number and endocrine therapy index in ER positive metastatic breast cancer patients

Costanza Paoletti
Meredith M. Regan
Samuel M. Niman
Emily M. Dolce
Elizabeth P. Darga
Minetta C. Liu
P. Kelly Marcom
Lowell L. Hart
John W. Smith
Karen L. Tedesco
Eitan Amir
Ian E. Krop
Angela M. DeMichele
Pamela J. Goodwin
Margaret Block
Kimberly Aung
Martha E. Brown
Robert T. McCormack
Daniel F. Hayes

June 2021

Abstract Circulating tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). The CTC-end...

Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

Abstract

Extracted data

Prognostic value of CEC count in HER2-negative metastatic breast cancer patients treated with bevacizumab and chemotherapy: a prospective validation study (UCBG COMET)

Abstract

Extracted data

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