Since the chance discovery, in 1967, of the anti-tumour activity of cisplatin, cis-dichlorodiammineplatinum(II), research has focussed on studying the reactions of this and other related complexes in an effort to elucidate the nature of the biological activity. This thesis presents a study of the aqueous solution chemistry of some platinum(II) and platinum(IV) complexes in order to extend what is known about the simple chemistry of this biologically important class of compounds. The chloride ion anation of diaqua (cis-[Pt(OH₂)₂(N)₂]²⁺) complexes is investigated as is the bromide ion anation of the bromoaqua (cis-[PtBr(OH₂)(N)₂]⁺) and diaqua (cis-[Pt(OH₂)₂(N)₂]²⁺) species, all in 1.0 M HC1O₄. The kinetics are studied using UV/Vis spectrosc...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...
Reported here is a study of the solution chemistry of the anti-cancer drug cis-dichloro-diammineplat...
Chloride anations of PtCl5H2O−, trans-PtCl4(H2O)2 and trans-Pt(CN)4ClH2O− in the presence of PtCl42−...
In this thesis reductions of model and anticancer active Pt(IV) complexes with thiols and ascorbic a...
The bromide anation of tr-PtCl4BrH2O− has been studied at 25 °C and the chloride anations of tr-PtCl...
Singly aquated and diaquated species are key intermediates in the mechanism responsible for the anti...
In this work, there are studied some biologically important platinum complexes, cisplatin analogues,...
In this work, there are studied some biologically important platinum complexes, cisplatin analogues,...
In this thesis mass spectral and chromatographic techniques were developed and applied to identify a...
The stepwise stabililty constants, Kn for the bromo aqua complexes PtBrn−1(H2O)7−n5−n; n=4, 5, 6, fo...
SynopsisVarious protolytic species of thiols RSH (thioglycolic acid, l-cysteine, dl-penicillamine, a...
Glutathione (GSH) reduction of the anticancer-active platinum(IV) compounds trans-[PtCl4(NH3)(thiazo...
Bromide anations of PtBr5H2O− in the presence of PtBr42− or bromine, of trans-PtBr4(H2O)2 in the pre...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...
Reported here is a study of the solution chemistry of the anti-cancer drug cis-dichloro-diammineplat...
Chloride anations of PtCl5H2O−, trans-PtCl4(H2O)2 and trans-Pt(CN)4ClH2O− in the presence of PtCl42−...
In this thesis reductions of model and anticancer active Pt(IV) complexes with thiols and ascorbic a...
The bromide anation of tr-PtCl4BrH2O− has been studied at 25 °C and the chloride anations of tr-PtCl...
Singly aquated and diaquated species are key intermediates in the mechanism responsible for the anti...
In this work, there are studied some biologically important platinum complexes, cisplatin analogues,...
In this work, there are studied some biologically important platinum complexes, cisplatin analogues,...
In this thesis mass spectral and chromatographic techniques were developed and applied to identify a...
The stepwise stabililty constants, Kn for the bromo aqua complexes PtBrn−1(H2O)7−n5−n; n=4, 5, 6, fo...
SynopsisVarious protolytic species of thiols RSH (thioglycolic acid, l-cysteine, dl-penicillamine, a...
Glutathione (GSH) reduction of the anticancer-active platinum(IV) compounds trans-[PtCl4(NH3)(thiazo...
Bromide anations of PtBr5H2O− in the presence of PtBr42− or bromine, of trans-PtBr4(H2O)2 in the pre...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...
Platinum(IV) complexes are an important class of compounds that can act as prodrugs, and due to thei...