In cataracts the lens of the eye becomes opaque. This can be caused by many different factors and can develop in a number of ways. Although the exact mechanism is unknown, many of the cortical cataracts display raised levels of calcium and increased proteolysis of the major lens proteins, the crystallins. This has lead several groups to investigate the possible involvement of the calcium-dependent proteases or calpains in cataracts. A line of sheep at Lincoln University inherits cataracts and provides an opportunity to investigate the role of calpain in cataract formation
AbstractThe Shumiya cataract rat (SCR) is a hereditary cataract model in which lens opacity appears ...
AbstractLenses cultured in diamide first developed outer cortical opacities followed by nuclear cata...
Aims: Proteolysis has been implied in cataract formation, but the proteases involved and their preci...
In cataracts the lens of the eye becomes opaque. This can be caused by many different factors and ca...
Calpains represent a family of non-lysosomal calcium-dependent proteases. Lenses from a variety of a...
In the lens, soluble crystallin proteins are tightly packed and ordered allowing passage of light to...
The absolute clarity of the lens of the eye is vital in the visual system. The unique structural and...
Objective To investigate biochemical changes accompanying Ca2+-induced lens opacification and the po...
The lens of the eye needs to be completely transparent in order to allow all light entering the eye ...
In humans, cataracts are a major cause of blindness. As such, extensive research is being pursued to...
A cataract is any opacity of the lens caused by unregulated protein aggregation. Cataracts are the m...
The lens of the eye needs to be completely transparent in order to allow all light entering the eye ...
The sheep lens culture system has been developed as an alternative, controlled model of cataract for...
The lens of the eye is a vital tissue in the visual system, responsible for the collection and focus...
During cataract formation increased lens calcium levels activate endogenous m-calpain. mCalpain is a...
AbstractThe Shumiya cataract rat (SCR) is a hereditary cataract model in which lens opacity appears ...
AbstractLenses cultured in diamide first developed outer cortical opacities followed by nuclear cata...
Aims: Proteolysis has been implied in cataract formation, but the proteases involved and their preci...
In cataracts the lens of the eye becomes opaque. This can be caused by many different factors and ca...
Calpains represent a family of non-lysosomal calcium-dependent proteases. Lenses from a variety of a...
In the lens, soluble crystallin proteins are tightly packed and ordered allowing passage of light to...
The absolute clarity of the lens of the eye is vital in the visual system. The unique structural and...
Objective To investigate biochemical changes accompanying Ca2+-induced lens opacification and the po...
The lens of the eye needs to be completely transparent in order to allow all light entering the eye ...
In humans, cataracts are a major cause of blindness. As such, extensive research is being pursued to...
A cataract is any opacity of the lens caused by unregulated protein aggregation. Cataracts are the m...
The lens of the eye needs to be completely transparent in order to allow all light entering the eye ...
The sheep lens culture system has been developed as an alternative, controlled model of cataract for...
The lens of the eye is a vital tissue in the visual system, responsible for the collection and focus...
During cataract formation increased lens calcium levels activate endogenous m-calpain. mCalpain is a...
AbstractThe Shumiya cataract rat (SCR) is a hereditary cataract model in which lens opacity appears ...
AbstractLenses cultured in diamide first developed outer cortical opacities followed by nuclear cata...
Aims: Proteolysis has been implied in cataract formation, but the proteases involved and their preci...