Add to ORKGContext: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate synthetase (ASS) is a promising candidate. Objective: Characterize ASS in APAP hepatotoxicity. Methods: ASS was measured in plasma from rodents and humans with APAP hepatotoxicity. Results: In mice, ASS increased before injury, peaked before alanine aminotransferase (ALT) and decreased rapidly. Fischer rats had a greater increase in ASS relative to ALT. Patients with abnormal liver test results had very high ASS compared to controls. ASS appeared to increase early in some patients, and declined rapidly in all. Conclusions: ASS may be a useful biomarker of acute cell death in APAP hepatotoxicity. © 2014 Informa UK Ltd. All rights reserved: rep...
The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigati...
International audienceAcute liver injury (ALI) is a severe disorder resulting from excessive hepatoc...
Context: Drug-induced liver injury is a significant worldwide clinical problem. Rosmarinic acid (RA)...
Contains fulltext : 108207.pdf (publisher's version ) (Open Access)Drug-induced li...
Background: Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen expo...
Background: Drug-induced liver injury is of great interest especially drugs that broadly used like a...
<div><p><i>Context:</i> Risk prediction following acetaminophen (paracetamol, APAP) overdose is base...
Acetaminophen (APAP), a commonly used over-the-counter analgesic, accounts for approximately fifty p...
BACKGROUND & AIMS: Acetaminophen overdose in mice is characterized by hepatocyte endoplasmic reticul...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate...
Acetaminophen (APAP) is the foremost cause of drug-induced liver injury in the Western world. Most s...
BACKGROUND & AIMS: Acetaminophen (APAP) overdose remains a frequent cause of acute liver failure...
A simple reversed-phase HPLC method for measuring hepatic levels of acetaminophen-(APAP-) protein ad...
International audienceBackground and aims: Acetaminophen is a common cause of poisoning and liver in...
The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigati...
International audienceAcute liver injury (ALI) is a severe disorder resulting from excessive hepatoc...
Context: Drug-induced liver injury is a significant worldwide clinical problem. Rosmarinic acid (RA)...
Contains fulltext : 108207.pdf (publisher's version ) (Open Access)Drug-induced li...
Background: Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen expo...
Background: Drug-induced liver injury is of great interest especially drugs that broadly used like a...
<div><p><i>Context:</i> Risk prediction following acetaminophen (paracetamol, APAP) overdose is base...
Acetaminophen (APAP), a commonly used over-the-counter analgesic, accounts for approximately fifty p...
BACKGROUND & AIMS: Acetaminophen overdose in mice is characterized by hepatocyte endoplasmic reticul...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate...
Acetaminophen (APAP) is the foremost cause of drug-induced liver injury in the Western world. Most s...
BACKGROUND & AIMS: Acetaminophen (APAP) overdose remains a frequent cause of acute liver failure...
A simple reversed-phase HPLC method for measuring hepatic levels of acetaminophen-(APAP-) protein ad...
International audienceBackground and aims: Acetaminophen is a common cause of poisoning and liver in...
The frequent use of rodent hepatic in vitro systems in pharmacological and toxicological investigati...
International audienceAcute liver injury (ALI) is a severe disorder resulting from excessive hepatoc...
Context: Drug-induced liver injury is a significant worldwide clinical problem. Rosmarinic acid (RA)...