Britain's often uneasy relationship with the European Union has become increasingly strained, leading to speculation that Britain is—sooner or later—headed towards an in-out referendum that will result in its withdrawal. Such a development would present both Britain and the EU with unprecedented challenges. Britain's debate about its future in the EU—its “European question”—creates a “British question” for the EU, the answers to which could change the EU's unity, leadership, prosperity and security with implications for wider European politics and academic analysis of European integration. This article sets out the links between these two questions. It does so by considering what the future of UK–EU relations could mean for the regional pol...