Synthesis and characterization of new tetralone esters

Podophyllotoxin belongs to the cyclolignan family of natural products.It exhibits cathartic, cytotoxic, antimitotic, anticancer and other biological activities. The new tetralone esters 4, 5, 6 and 7 of podophyllotoxin analogues were synthesized in very good yields by chalcone route. They were synthesized by modifying 1,3-methylene dioxy ring A, ring C, the lactone ring D and the ringE of podophyllotoxin 1 to study structure activity relationship. All the products were characterized by spectral and elemental analysis data