Synthesis and antimicrobial activity of novel isoxazolines by 1, 3-dipolar cycloaddition reactions

Nitrile oxides were generated by the catalytic dehydrogenation of aromatic aldehyde oximes 2a-g with chloramine-T as oxidizing agent. The 1,3-dipolar cycloaddition of in situ generated nitrile oxides with ethyl oleate 1 produced a series of new ethyl 8-(3-aryl-4-octyl-4,5-dihydroisoxazol-5-yl)octanoate 3a-g in 65- 84 yield. Some of the synthesized cycloadducts have exhibited moderate to good antifungal and antibacterial activity