Antihyperglycemic and hypolipidemic effect of Morus Indica L. in streptozotocin induced diabetic rats

The present study evaluated the long term hypoglycemic effect of Morus indica L. in rats induced with diabetes, to determine the changes in activity of glycolytic and gluconeogenic enzymes and to compare the effect of Morus indica L. with conventional antidiabetic drugs - Insulin and Glibenclamide (OHA). Morus indica L. was obtained from the Department of Studies in Sericulture, University of Mysore, India. The antihyperglycemic effect of the plant was tested in streptozotocin induced diabetic rats. The effect of Morus indica L. on carbohydrate metabolizing enzymes was also studied. Morus indica powder (MIP) at a level of 500mg/kg body weight, reduced blood glucose level in the animals by 42 after 45 days. The blood glucose in animals supplemented with MIP decreased from an initial level of 257± 69.4 to 148.8 ± 34.48 mg/dl. The activity of aldolase in the liver of MIP and Insulin treated groups was 0.19u/g and in Glibenclamide treated group, it was 0.18u/g protein. The activity of G-6-PDH decreased significantly (p