A Facile Route for the Synthesis of Ethyl N-aryl-2,6-dioxo-piperid-3-ene-4-carboxylates and their Biological Activity

Cyclopropyl derivatives and piperidinediones have known to exhibit enormous amount of biological activities. In the present study the synthesis of biologically potent ethyl N-aryl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylates (2), N-aryl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acids (3) and ethyl 2,6-dioxo-N-aryl-piperid-3-ene-4-carboxylates (4) were described. The compounds (2, 4) were evaluated in vitro for their antibacterial, antifungal, antioxidant and reducing ability. The findings revealed that compounds (2) may be used as control measures against different bacterium and fungi, and (4) can be used as reference standard for antioxidant activities