Overview of pediatric oral dosage forms in the Republic of Macedonia

The paediatric drug development is associated with numerous challenges. As a result, only a fraction of all medicines are licensed for use in children globally. Traditional oralsolid medicines are frequently usedin children, mostly due to their stability, dose uniformity and costs. On the other hand, novel oral dosage forms offer dose flexibility and individualized therapy on the basis of paediatricage groups and inter-individual variations. Such noveloral formulations include mini-tablets, chewable and orodispersibletablets, and dosage forms dispersible into liquids or mixed with food. The inadequate marketing of paediatric medicines isof concern especially in countries with limited healthcare budgets, impeding patient access to innovative products with tangible therapeutic benefits