Survival in initially metastatic breast carcinoma

Approximately 5%-10% of patients with breast cancer have distant metastases at first presentation. Chemotherapy or hormone therapy is often the main treatment in these patients without loco-regional treatment (surgery or radiotherapy) except in cases of fungation forms and bleeding. There are studies that have shown that removal of primary tumor at times leads to complete disappearance of metastases and improvement in survival in renal cell carcinoma patients. However, such studies have never been performed in other solid tumors. On the other hand, there is a strong body of evidence in experimental settings showing that removal of primary tumor allows growth of metastasis. There is lack of similar data in humans in clinical settings. Breast cancer as a biological and genetically heterogeneous tumor often metastasizes to the bone so patients with bone metastases form the largest group of patients with metastatic disease. The incidence is significantly high in steroid receptor positive tumors and well-differentiated lesions. Approximately 50% of patients with metastatic bone disease have clinical symptoms, and in 4% -7% develop pathological fractures of the long bones. Patients with bone metastases from breast cancer are with better survival than from other tumors. Recent data suggest that survival may be improved if disease is controlled by offering loco-regional treatment of the primary tumor in metastatic breast cancer. This a case report about 44 years old femail patient with breast cancer with diffuse bone metastases at first presentation