Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project.
- Shaaban, Abeer M
- Hilton, Bridget
- Clements, Karen
- Provenzano, Elena
- Cheung, Shan
- Wallis, Matthew G
- Sawyer, Elinor
- Thomas, Jeremy S
- Hanby, Andrew M
- Pinder, Sarah E
- Thompson, Alastair M
DOIAbstract
BACKGROUND The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. METHODS This was a national, prospective cohort study of DCIS diagnosed during 2003-2012. RESULTS Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of high-grade disease increased (from 60 to 65%), low-grade DCIS decreased (from 10 to 6%) and mean size increased (from 21.4 to 24.1 mm). Mastectomy was more common for high-grade (36%) than for low-grade DCIS (15%). Few (6%) patients treated with breast-conserving surgery (BCS) had a surgical margin <1 mm. Of the 9191 women diagnosed in England (median follow-up 9.4 years), 7% developed DCIS or invasive malignancy ...
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