The Study of Prevalence of Lipid Profile Abnormalities and its correlation with cardiovascular diseases regarding different environmental and genetic factors in Hemodialysis Patients of Vasee Hospital of Sabzevar in 2015

Introduction: Lipid disorders is a highly prevalent in patients on dialysis. Also the risk of cardiovascular disease increases with kidney failure. This study was conducted to evaluate the Prevalence of lipid profile abnormalities and its correlation with cardiovascular diseases regarding different environmental and genetic factors in hemodialysis patients of Vasee Hospital of Sabzevar in 2015. Method: This study was a cross–sectional that were evaluated all Patients that at least 12 weeks were on dialysis. Patient data includes demographic data and blood tests including serum levels of total cholesterol, triglycerides, HDL and LDL were extracted from medical records. Then the patient identifies and follow up and underwent echocardiography. Results: 54 patients were enrolled including 29 men (53.7%) and 25 women (46.3%). 31.5% of they, had abnormal serum triglycerides, 11.1% had abnormal serum cholesterol levels, 14.8% had abnormal serum levels of LDL and 72.2% had abnormal serum levels of HDL. The average of EF were 50.9±14.6% in patients. In terms of diastolic function, 29.6% had a normal function, 48.1% had grade 1 diastolic dysfunction, 14.8% had grade 2 diastolic dysfunction and 7.4% had grade 3 diastolic dysfunction. The association between duration of dialysis with Systolic and diastolic function was not significant. However, the amount of E, reduced with increasing duration of dialysis and PWDd and IVSd somewhat increased. There was no significant relationship between Systolic and diastolic function and dyslipidemia. However, in people who had dyslipidemia, the amount of EF was somewhat less and LViDs, LViDd and PWDd was over in this people. In addition, the E, A and Sm were also lower in these patients. Conclusion: Kidney failure is one of effective factors in the development dyslipidemia. It is recommended that review lipid profile and also blood pressure values in all cases with kidney failure and if needed to treatment, follow-up to be necessary. Also be checked in terms of cardiac dysfunction, all patients with dyslipidemia. Keywords: Dyslipidemia, Chronic renal failure, Dialysis, Cardiovascular disease, Echocardiograph