The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer

Wang Shou
Igawa Kazuyo
Ogawara Ryo
Suda Mitsuru
Hamano Tsuyoshi
Ibaragi Soichiro
Hanafusa Tadashi
Ichikawa Yasuaki
Sasaki Akira

Open link

Publication date

November 2020

DOI

10.1016/j.apradiso.2020.109271

Publisher

Elsevier BV

Journal

Applied Radiation and Isotopes

Abstract

The purpose of this study is to assess accelerator-based boron neutron capture reaction (BNCR) in human tumor cell lines by colony formation assay and modified high density survival assay (HDS assay). The results of post irradiation survival rate in human oral squamous cell carcinoma and osteosarcoma using both assays were similar. Therefore, HDS assay would be efficient to evaluate BNCR in not only tumor cells but also in normal cells as BNCT screening