Enhanced Cell Inactivation and Double-strand Break Induction in V79 Chinese Hamster Cells by Monochromatic X-rays at Phosphorus K-shell Absorption Peak

To investigate an enhancement of cell inactivation and DNA double-strand break (DSB) induction by the K-shell ionization of phosphorus atoms and Auger electrons, monochromatic X-rays on and below the phosphorus K-shell absorption peak, 2.153 keV and 2.147 keV were exposed to Chinese hamster lung fibroblast V79 cells. Survival fractions were plotted against exposure, Ψ [nC/kg] and the linear-quadratic (LQ) model was adapted to estimate the parameters, α and β, of the survival curves. DSB induction rate [DSB/cell/Ψ] was estimated from the measured fractions of induced DNA fragments below 4.6 Mbp (Fk