We examined neural network ontogeny using microelectrode array (MEA) recordings made in multiwell MEA (mwMEA) plates over the first 12 days in vitro (DIV). In primary cortical cultures, action potential spiking activity developed rapidly between DIV 5 and 12. Spiking was sporadic and unorganized at early DIV, and became progressively more organized with time, with bursting parameters, synchrony, and network bursting increasing between DIV 5 and 12. We selected 12 features to describe network activity; principal components analysis using these features demonstrated segregation of data by age at both the well and plate levels. Using random forest classifiers and support vector machines, we demonstrated that four features (coefficient of varia...
This study presents sensing of network bursts in a three-dimensional (3D) cell culture system consis...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
The cortex is spontaneously active, even in the absence of any particular input or motor output. Dur...
Technological advancement through the last century have made it possible to not only culture neurons...
Abstract—It is an open question whether neuronal networks, cultured on multielectrode arrays, retain...
Abstract—It is an open question whether neuronal networks, cultured on multielectrode arrays, retain...
Abstract Background We have collected a comprehensive set of multi-unit data on dissociated cortical...
BACKGROUND: Neural circuits can spontaneously generate complex spatiotemporal firing patterns during...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
is an open question whether neuronal networks, cultured on multielectrode arrays, retain any capabil...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
Abstract In vitro model networks could provide cellular models of physiological relevance to reprodu...
This study presents sensing of network bursts in a three-dimensional (3D) cell culture system consis...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
The cortex is spontaneously active, even in the absence of any particular input or motor output. Dur...
Technological advancement through the last century have made it possible to not only culture neurons...
Abstract—It is an open question whether neuronal networks, cultured on multielectrode arrays, retain...
Abstract—It is an open question whether neuronal networks, cultured on multielectrode arrays, retain...
Abstract Background We have collected a comprehensive set of multi-unit data on dissociated cortical...
BACKGROUND: Neural circuits can spontaneously generate complex spatiotemporal firing patterns during...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
is an open question whether neuronal networks, cultured on multielectrode arrays, retain any capabil...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
Abstract In vitro model networks could provide cellular models of physiological relevance to reprodu...
This study presents sensing of network bursts in a three-dimensional (3D) cell culture system consis...
Comprehensive electrophysiological characterizations of human induced pluripotent stem cell (hiPSC)-...
The cortex is spontaneously active, even in the absence of any particular input or motor output. Dur...