For every smooth complex projective variety W of dimension d and nonnegative Kodaira dimension, we show the existence of a universal constant m depending only on d and two natural invariants of the very general fibres of an Iitaka fibration of W such that the pluricanonical system | mKW| defines an Iitaka fibration. This is a consequence of a more general result on polarized adjoint divisors. In order to prove these results we develop a generalized theory of pairs, singularities, log canonical thresholds, adjunction, etc.The first author was partially supported by a grant of the Leverhulme Trust. Part of this work was done when the first author visited National University of Singapore in April 2014. Part of this work was done when the first...