The chondrocyte is the cell responsible for the maintenance of the articular cartilage matrix. The negative charges of proteoglycans of the matrix draw cations, principally Na+, into the matrix to balance the negative charge distribution. The Na+,Kf -ATPase is the plasma membrane enzyme that maintains the intracellular Na+ and K+ concentrations. The enzyme is composed of an α and a β subunit, so far, 4α and 3β isoforms have been identified in mammals. Chondrocytes are sensitive to their ionic and osmotic environment and are capable of adaptive responses to ionic environmental perturbations particularly changes to extracellular [Na+]. In this article we show that human fetal and adult chondrocytes express three α (α1, α2 and the neural form ...
The plasma membrane abundance of the Na+/K+ pump or Na+,K+-ATPase depends on the intracellular conce...
The catalytic a isoforms of the Na+, K+- ATPase and stimuli controlling the plasma membrane abundanc...
The catalytic alpha isoforms of the Na+, K(+)-ATPase and stimuli controlling the plasma membrane abu...
The chondrocyte is the cell responsible for the maintenance of the articular cartilage matrix. The n...
The chondrocyte is the cell responsible for the maintenance of the articular cartilage matrix. The n...
The maintenance of a relatively low intracellular Na+:K+ ratio is essential for the functioning of a...
Sodium transport systems in human chondrocytes Morphological and functional expression of the Na+,K+...
Membrane transport systems participate in fundamental activities such as cell cycle control, prolife...
The abundance of Na+, K+-ATPase in cartilage is controlled by the ionic composition of the extracell...
Membrane transport systems participate in fundamental activities such as cell cycle control, prolife...
In this article, the second of two, we continue our studies of sodium-dependent transport systems in...
In this article, the second of two, we continue our studies of sodium-dependent transport systems in...
Chondrocytes exist in an unusual and variable ionic and osmotic environment in the extracellular mat...
Chondrocytes exist in an unusual and variable ionic and osmotic environment in the extracellular mat...
We have used isoform-specific antibodies against the Na+, K(+)-ATPase alpha (alpha 1, alpha 2 and al...
The plasma membrane abundance of the Na+/K+ pump or Na+,K+-ATPase depends on the intracellular conce...
The catalytic a isoforms of the Na+, K+- ATPase and stimuli controlling the plasma membrane abundanc...
The catalytic alpha isoforms of the Na+, K(+)-ATPase and stimuli controlling the plasma membrane abu...
The chondrocyte is the cell responsible for the maintenance of the articular cartilage matrix. The n...
The chondrocyte is the cell responsible for the maintenance of the articular cartilage matrix. The n...
The maintenance of a relatively low intracellular Na+:K+ ratio is essential for the functioning of a...
Sodium transport systems in human chondrocytes Morphological and functional expression of the Na+,K+...
Membrane transport systems participate in fundamental activities such as cell cycle control, prolife...
The abundance of Na+, K+-ATPase in cartilage is controlled by the ionic composition of the extracell...
Membrane transport systems participate in fundamental activities such as cell cycle control, prolife...
In this article, the second of two, we continue our studies of sodium-dependent transport systems in...
In this article, the second of two, we continue our studies of sodium-dependent transport systems in...
Chondrocytes exist in an unusual and variable ionic and osmotic environment in the extracellular mat...
Chondrocytes exist in an unusual and variable ionic and osmotic environment in the extracellular mat...
We have used isoform-specific antibodies against the Na+, K(+)-ATPase alpha (alpha 1, alpha 2 and al...
The plasma membrane abundance of the Na+/K+ pump or Na+,K+-ATPase depends on the intracellular conce...
The catalytic a isoforms of the Na+, K+- ATPase and stimuli controlling the plasma membrane abundanc...
The catalytic alpha isoforms of the Na+, K(+)-ATPase and stimuli controlling the plasma membrane abu...