Levels of aminotransferases and lactate dehydrogenase in pregnant and preeclampsia fetuses

Preeclampsia results in uteroplacental insufficiency which causes hypoxia to the fetus. Hypoxia causes biochemical changes in the fetal and pregnant liver by altering the concentration of biochemical parameters in maternal and fetal blood. Purpose of the study: to determine the level of aminotransferases (ALT, AST) and lactate dehydrogenase in pregnant and fetal / neonatus blood of normal and preeclamptic pregnancy Material and methods: 80 pregnant women were included in the study, 40 of whom had normal pregnancies and 40 preeclamptic pregnancies with increased retardation (IUGR), in both groups blood was drawn from the cubic vein to determine AST, ALT and LDH in pregnant women and the fetus/neonatus. Pregnancy age is determined by the formula of recent menstruation and fetal biometrics. Results were determined by the Mann-Whitney U test for non-parametric numerical variables destroyed in the independent groups. Results: AST values in pregnant women with preeclampsia are higher compared to physiological pregnancies [U = 521,500, z = 6.717, p \u3c0.001]. ALT values in pregnant women with preeclampsia are higher than in physiological pregnant women [U = 554,000, z = 6,560, p \u3c0.001]. LDH values are higher in preeclamptic pregnancy compared to physiological pregnancy [U = 1131.500, z = 3.509, p \u3c0.001]. The AST values in fetal/neonatus blood with IUGR are higher than normal-growth fetal values [U = 1333,000, z = 2,454, p \u3c0.014]. ALT values in the fetus/neonate with IUGR are higher compared to the fetus with normal growth [U = 908,000, z = 4,698, p \u3c0.001]. LDH values in fetal/neonatus blood with IUGR are higher compared to fetuses with normal growth [U = 1203,000, z = 3.135, p \u3c0.002]. Conclusions: In preeclamptic pregnancy the values of AST, ALT and LDH are higher compared to physiological pregnancy. In fetal/neonatus with IUGR values of AST, ALT, LDH are higher compared to normal-growing fetus/neonatus