The cancer microenvironment is known for its complexity, both in its content as well as its dynamic nature, which is difficult to study using two-dimensional (2D) cell culture models. Several advances in tissue engineering have allowed more physiologically relevant three-dimensional (3D) in vitro cancer models, such as spheroid cultures, biopolymer scaffolds, and cancer-on-a-chip devices. Although these models serve as powerful tools for dissecting the roles of various biochemical and biophysical cues in carcinoma initiation and progression, they lack the ability to control the organization of multiple cell types in a complex dynamic 3D architecture. By virtue of its ability to precisely define perfusable networks and position of various ce...
In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor growth,...
The classic cell culture involves the use of support in two dimensions, such as a well plate or a Pe...
The National Cancer Institute estimates that approximately 40% of men and women will be diagnosed wi...
The tumor microenvironment (TME) typically comprises cancer cells, tumor vasculature, stromal compon...
The complex and heterogenous nature of cancer contributes to the development of cancer cell drug res...
Tumor cells evolve in a complex and heterogeneous environment composed of different cell types and a...
Even with many advances in treatment over the past decades, cancer still remains a leading cause of ...
Innovative drug screening platforms should improve the discovery of novel and personalized cancer tr...
Cancer is becoming one the leading causes of death worldwide, and in particular, breast cancer, whic...
After cardiovascular disease, cancer is the leading cause of death worldwide with devastating health...
Combinatorial conjugation of organ-on-a-chip platforms with additive manufacturing technologies is r...
The bioprinting technique with specialized tissue production allows the study of biological, physiol...
Understanding the microenvironmental factors that control cell function, differentiation, and stem c...
The extracellular matrix (ECM) is a critical cue to direct tumorigenesis and metastasis. Although tw...
Malignant melanoma is often used as a model tumor for the establishment of novel therapies. It is kn...
In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor growth,...
The classic cell culture involves the use of support in two dimensions, such as a well plate or a Pe...
The National Cancer Institute estimates that approximately 40% of men and women will be diagnosed wi...
The tumor microenvironment (TME) typically comprises cancer cells, tumor vasculature, stromal compon...
The complex and heterogenous nature of cancer contributes to the development of cancer cell drug res...
Tumor cells evolve in a complex and heterogeneous environment composed of different cell types and a...
Even with many advances in treatment over the past decades, cancer still remains a leading cause of ...
Innovative drug screening platforms should improve the discovery of novel and personalized cancer tr...
Cancer is becoming one the leading causes of death worldwide, and in particular, breast cancer, whic...
After cardiovascular disease, cancer is the leading cause of death worldwide with devastating health...
Combinatorial conjugation of organ-on-a-chip platforms with additive manufacturing technologies is r...
The bioprinting technique with specialized tissue production allows the study of biological, physiol...
Understanding the microenvironmental factors that control cell function, differentiation, and stem c...
The extracellular matrix (ECM) is a critical cue to direct tumorigenesis and metastasis. Although tw...
Malignant melanoma is often used as a model tumor for the establishment of novel therapies. It is kn...
In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor growth,...
The classic cell culture involves the use of support in two dimensions, such as a well plate or a Pe...
The National Cancer Institute estimates that approximately 40% of men and women will be diagnosed wi...